The production of matured mRNA requires multiple processing steps, spanning from transcription down to translation. These highly dynamic processes regulate both transcriptome and proteome. Notably, abnormal mRNA processing is frequently observed in cells and is associated with various diseases. Thus, it is essential to reprogram mRNA processing using small molecules, to both gain a deeper understanding of the underlying mechanisms and to explore potential therapeutic applications. As a chemical biology lab, we aim to combine novel optochemical genetics tools, gene expansion techniques, molecular biology and bioengineering, to investigate those important biological events.